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SAFETY DATA SHEETS According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition Version: 1.0 Creation Date: Aug 18, 2017 Revision Date: Aug 18, 2017 1. Identification 1.1 GHS Product identifier Product name (2S,3R,4S,5R)-2-(2-hydroxypropyl)oxane-3,4,5-triol 1.2 Other means of identification Product number - Other names Hydroxypropyl tetrahydropyrantriol 1.3 Recommended use of the chemical and restrictions on use Identified uses For industry use only. Uses advised against no data available 1.4 Supplier's details Company MOLBASE (Shanghai) Biotechnology Co., Ltd. Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China Telephone +86(21)64956998 Fax +86(21)54365166 1.5 Emergency phone number Emergency phone number +86-400-6021-666 Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). 2. Hazard identification 2.1 Classification of the substance or mixture no data available 2.2 GHS label elements, including precautionary statements Pictogram(s) no data available Signal word no data available Hazard statement(s) no data available Precautionary statement(s) Prevention no data available Response no data available Storage no data available Disposal no data available 2.3 Other hazards which do not result in classification no data available 3. Composition/information on ingredients 3.1 Substances Chemical name Common names and synonyms CAS number EC number Concentration (2S,3R,4S,5R)-2-(2-hydroxypropyl)oxane-3,4,5-triol (2S,3R,4S,5R)-2-(2-hydroxypropyl)oxane-3,4,5-triol 439685-79-7 none 100% 4. First-aid measures 4.1 Description of necessary first-aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms/effects, acute and delayed no data available 4.3 Indication of immediate medical attention and special treatment needed, if necessary no data available 5. Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Specific hazards arising from the chemical no data available 5.3 Special protective actions for fire-fighters Wear self-contained breathing apparatus for firefighting if necessary. 6. Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal. 7. Handling and storage 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. 8. Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit values no data available Biological limit values no data available 8.2 Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. 8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards no data available 9. Physical and chemical properties Physical state no data available Colour no data available Odour no data available Melting point/ freezing point no data available Boiling point or initial boiling point and boiling range no data available Flammability no data available Lower and upper explosion limit / flammability limit no data available Flash point no data available Auto-ignition temperature no data available Decomposition temperature no data available pH no data available Kinematic viscosity no data available Solubility no data available Partition coefficient n-octanol/water (log value) no data available Vapour pressure no data available Density and/or relative density no data available Relative vapour density no data available Particle characteristics no data available 10. Stability and reactivity 10.1 Reactivity no data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions no data available 10.4 Conditions to avoid no data available 10.5 Incompatible materials no data available 10.6 Hazardous decomposition products no data available 11. Toxicological information Acute toxicity Oral: no data available Inhalation: no data available Dermal: no data available Skin corrosion/irritation no data available Serious eye damage/irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity no data available Reproductive toxicity no data available STOT-single exposure no data available STOT-repeated exposure no data available Aspiration hazard no data available 12. Ecological information 12.1 Toxicity Toxicity to fish: no data available Toxicity to daphnia and other aquatic invertebrates: no data available Toxicity to algae: no data available Toxicity to microorganisms: no data available 12.2 Persistence and degradability no data available 12.3 Bioaccumulative potential no data available 12.4 Mobility in soil no data available 12.5 Other adverse effects no data available 13. Disposal considerations 13.1 Disposal methods Product The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems. Contaminated packaging Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials. 14. Transport information 14.1 UN Number ADR/RID: no data available IMDG: no data available IATA: no data available 14.2 UN Proper Shipping Name ADR/RID: no data available IMDG: no data available IATA: no data available 14.3 Transport hazard class(es) ADR/RID: no data available IMDG: no data available IATA: no data available 14.4 Packing group, if applicable ADR/RID: no data available IMDG: no data available IATA: no data available 14.5 Environmental hazards ADR/RID: no IMDG: no IATA: no 14.6 Special precautions for user no data available 14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code no data available 15. Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question Chemical name Common names and synonyms CAS number EC number (2S,3R,4S,5R)-2-(2-hydroxypropyl)oxane-3,4,5-triol (2S,3R,4S,5R)-2-(2-hydroxypropyl)oxane-3,4,5-triol 439685-79-7 none European Inventory of Existing Commercial Chemical Substances (EINECS) Not Listed. EC Inventory Not Listed. United States Toxic Substances Control Act (TSCA) Inventory Not Listed. China Catalog of Hazardous chemicals 2015 Not Listed. New Zealand Inventory of Chemicals (NZIoC) Not Listed. Philippines Inventory of Chemicals and Chemical Substances (PICCS) Not Listed. Vietnam National Chemical Inventory Not Listed. Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Not Listed. 16. Other information Information on revision Creation Date Aug 18, 2017 Revision Date Aug 18, 2017 Abbreviations and acronyms CAS: Chemical Abstracts Service ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road RID: Regulation concerning the International Carriage of Dangerous Goods by Rail IMDG: International Maritime Dangerous Goods IATA: International Air Transportation Association TWA: Time Weighted Average STEL: Short term exposure limit LC50: Lethal Concentration 50% LD50: Lethal Dose 50

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产品名称： INCI 名：羟丙基四氢吡喃三醇 别名：玻色因 商品名称：倍瑟因 CAS 号：439685-79-7 性能作用： 1. 可以促进糖胺聚糖（GAGs）的合成，促进蛋白聚糖修复与生成，进而使真皮内细胞外基质（ECM）丰富与提高含水量。 2.可通过CD44促进透明质酸的合成，增加真皮内透明质酸含量。 3.能够重建表皮-真皮层完整结构，同时也有和维A酸类似功能---增强角质层的厚度，使屏障功能完善，但是没有丝毫的刺激性。 理化性质 外观 ：白色至类白色粉末 色谱鉴定 ：与标准样品保留时间比较一致 理化鉴定 ：与标准一致 水分 ：≤3.0% 炽灼残渣 ：≤3.0% 纯度 ：≥99.0% 手性纯度（S 型） ：≥90.0% 乙酸乙酯 ：≤5000mg/kg 菌落总数 ：≤100cfu/g

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